Abstract #2522

Correlation of Vessel Abnormality Quantification from TOF MRA with Histologic and Gene Markers

Maddalena Strumia^1,2,3, Wilfried Reichardt^1,2,3, Ori Staszewski⁴, Dieter Henrik Heiland⁵, Astrid Weyerbrock⁵, Irina Mader⁶, and Michael Bock²

¹German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Medical Physics, University Medical Center Freiburg, Freiburg, Germany, ³Deutsches Konsortium für Translationale Krebsforschung (DKTK), Heidelberg, Germany, ⁴Neuropathology, University Medical Center Freiburg, Freiburg, Germany, ⁵Neurosurgery, University Medical Center Freiburg, Freiburg, Germany, ⁶Neuroradiology, University Medical Center Freiburg, Freiburg, Germany

The glioblastoma is one of the most malignant and aggressive tumors of the brain-white-matter, and it expressing vascular-endothelial-grow-factors to initiate and maintain angiogenesis. To assess whether a novel therapeutic drug inhibits neo-angiogenesis, non-invasive imaging methods to study changes of neo-angiogenic vasculature are needed. In this work we show a correlation between a quantification measure of the pathological vessels structure, the dot product, and histology and genetic markers, in glioblastomas using TOF-MRA data. The correlation has been applied to 11 patients and shows that morphologic markers can be correlated with histologic and genetic markers to assess tumor vasculature.

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