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Abstract #2522

Correlation of Vessel Abnormality Quantification from TOF MRA with Histologic and Gene Markers

Maddalena Strumia1,2,3, Wilfried Reichardt1,2,3, Ori Staszewski4, Dieter Henrik Heiland5, Astrid Weyerbrock5, Irina Mader6, and Michael Bock2

1German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Medical Physics, University Medical Center Freiburg, Freiburg, Germany, 3Deutsches Konsortium für Translationale Krebsforschung (DKTK), Heidelberg, Germany, 4Neuropathology, University Medical Center Freiburg, Freiburg, Germany, 5Neurosurgery, University Medical Center Freiburg, Freiburg, Germany, 6Neuroradiology, University Medical Center Freiburg, Freiburg, Germany

The glioblastoma is one of the most malignant and aggressive tumors of the brain-white-matter, and it expressing vascular-endothelial-grow-factors to initiate and maintain angiogenesis. To assess whether a novel therapeutic drug inhibits neo-angiogenesis, non-invasive imaging methods to study changes of neo-angiogenic vasculature are needed. In this work we show a correlation between a quantification measure of the pathological vessels structure, the dot product, and histology and genetic markers, in glioblastomas using TOF-MRA data. The correlation has been applied to 11 patients and shows that morphologic markers can be correlated with histologic and genetic markers to assess tumor vasculature.

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