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Abstract #2532

Long-Term Effect of Persistent Microvascular Obstruction on Adverse Post-Infarction Ventricular Remodeling via Prolonged Iron-Driven Inflammatory Process: a Cardiac Magnetic Resonance Study with Ex-vivo Validation

Ivan Cokic1, Avinash Kali1, Hsin-Jung Yang1, Richard Tang1, Frank S Prato2, David Underhill1, and Rohan Dharmakumar1

1Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Lawson Health Research Institute, London, ON, Canada

Hemorrhagic myocardial infarctions (MI) are associated with persistence of iron depositions in the chronic MI phase. These iron deposits have been shown to lead to perpetual recruitment of new monocytes/macrophages into the infarcted territory. Hemorrhagic MI is accompanied by a persistent microvascular obstruction (PMO) but the converse is not true. In this histologically validated cardiac MRI study we demonstrate that even in the absence of hemorrhage, PMO per se can lead to chronic iron-driven inflammatory response. Our findings are expected and lend improved insight into the mechanisms driving heart failure in infarction with PMO.

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