Abstract #2536

Metabolic alterations in chemotherapy-induced cardiotoxicity revealed by in vivo hyperpolarized 13C-MRS

Michael S Dodd¹, Vicky Ball¹, and Damian J Tyler¹

¹Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

Doxorubicin can lead to pre-clinical and clinical heart failure and reduced myocardial energetics. Alterations in metabolism potentially play a role in chemotherapy induced heart failure. The aim of this work was to assess the in vivo metabolic phenotype of doxorubicin treated hearts using hyperpolarized MRS. Doxorubicin cardiotoxicity was induced in Wistar rats and 4 weeks later, CINE-MRI and hyperpolarized [1-¹³C]pyruvate MRS was performed. Doxorubicin resulted in significant wall thinning, and reductions in both cardiac function and volume, all indicative of cardiotoxicity. Interestingly, doxorubicin resulted in significant metabolic alterations; with reductions in both PDH flux and ¹³C label incorporation into alanine.

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