Abstract #2535

The Effect of Hypertrophy in CardioCEST Magnetization Transfer Contrast

Scott William Thalman¹, Zhengshi Yang², Ashley Pumphrey², and Moriel Vandsburger^1,2,3

¹Department of Biomedical Engineering, University of Kentucky, Lexington, KY, United States, ²Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, United States, ³Department of Physiology, University of Kentucky, Lexington, KY, United States

Remodeling of the myocardium via hypertrophy and fibrosis increases the risk of adverse cardiac events. Quantitative magnetization transfer weighted imaging has shown promise as a method to identify fibrosis, however the effects of hypertrophy on such measures remains unknown. Using a murine model of chronic Angiotensin-II stimulation characterized by robust hypertrophy with little fibrosis, we demonstrate that despite large increases in myocardial mean cross-sectional area (AngII= 4825μm²±717 vs Saline= 2372μm²±158), no change occurs in the cardioCEST derived measure of magnetization transfer ratio (MTR) (AngII= 30.8%±7.3 vs Saline= 27.2%±8.6). Thus, increases in MTR due to fibrosis are unbiased by concomitant hypertrophy.

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