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Abstract #2534

MRI characterisation of iron overload in a humanised mouse model of β-thalassemia major

Laurence H Jackson1, Evangelia Vlachodimitropoulou Koumoutsea2, Panicos Shangaris3, Thomas M Ryan4, Anna L David3, John Porter2, Daniel J Stuckey1, and Mark F Lythgoe1

1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 2Dept. Haematology, University College London, London, United Kingdom, 3Institute for Women’s Health, University College London, London, United Kingdom, 4Dept. Biochemistry and Molecular Genetics, University of Alabama, Birmingham, AL, United States

β-thalassemia major is a common blood disorder causing the production of abnormal red blood cells (RBCs) leading to severe anaemia. Current treatment of the disease consists of regular blood transfusions with the side effect of iron overload. Due to difficulties in producing a representative animal model of the disease, research into experimental therapy has been limited. A recently developed humanised mouse model of thalassemia has the potential to provide a platform for the development of new treatments. Here we determine whether magnetic resonance imaging (MRI) can be used to assess and quantify biomarkers of disease in-vivo.

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