Abstract #2538

In Vivo, High-Frequency 3D Cardiac Magnetic Resonance Elastography: Feasibility in Normal Volunteers

Arvin Arani¹, Kevin J. Glaser¹, Shivaram Poigai Arunachalam¹, Phillip J. Rossman¹, David S. Lake¹, Joshua D. Trzasko¹, Armando Manduca¹, Kiaran P. McGee¹, Richard L. Ehman¹, and Philip A. Araoz¹

¹Mayo Clinic, Rochester, MN, United States

Noninvasive stiffness imaging techniques (elastography) can image myocardial tissue biomechanics in vivo. However, for cardiac magnetic resonance elastography (MRE) techniques the optimal vibration frequency for in vivo experiments is unknown. The purpose of this study was to determine the optimal vibration frequency for cardiac MRE in healthy volunteers. Cardiac MRE displacement fields can be imaged with mean OSS-SNR > 1.6 at frequencies as high as 180Hz, however, mean OSS-SNR values and myocardial coverage was shown to be highest at 140Hz across all subjects. This study motivates future evaluation of high-frequency 3D MRE in patient populations.

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