Abstract #2539

In-vivo assessment of myocardial stiffness in a pig with induced myocardial infarction using 3D Magnetic Resonance Elastography

Shivaram Poigai Arunachalam¹, Arvin Arani¹, Francis Baffour¹, Joseph Rysavy², Phillip Rossman¹, David Lake³, Kevin Glaser¹, Joshua Trzasko¹, Armando Manduca³, Kiaran McGee¹, Richard Ehman¹, and Philip Araoz¹

¹Radiology, Mayo Clinic, Rochester, MN, United States, ²Surgery, Mayo Clinic, Rochester, MN, United States, ³Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States

Myocardial stiffness is a novel biomarker with both diagnostic and prognostic potential for a range of cardiac diseases such as myocardial infarction which is known to significantly increase stiffness. Magnetic Resonance Elastography (MRE) is a non-invasive imaging technique that can be applied to the heart for in-vivo myocardial tissue characterization. The purpose of this pilot study was to assess the feasibility of measuring in-vivo stiffness changes in infarcted tissue and compare with remote (i.e. non-infarcted) myocardium in the same pig using 3D MRE. Results indicate a 3-fold increase in stiffness of the infarct compared to the normal myocardium.

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