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Abstract #2539

In-vivo assessment of myocardial stiffness in a pig with induced myocardial infarction using 3D Magnetic Resonance Elastography

Shivaram Poigai Arunachalam1, Arvin Arani1, Francis Baffour1, Joseph Rysavy2, Phillip Rossman1, David Lake3, Kevin Glaser1, Joshua Trzasko1, Armando Manduca3, Kiaran McGee1, Richard Ehman1, and Philip Araoz1

1Radiology, Mayo Clinic, Rochester, MN, United States, 2Surgery, Mayo Clinic, Rochester, MN, United States, 3Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States

Myocardial stiffness is a novel biomarker with both diagnostic and prognostic potential for a range of cardiac diseases such as myocardial infarction which is known to significantly increase stiffness. Magnetic Resonance Elastography (MRE) is a non-invasive imaging technique that can be applied to the heart for in-vivo myocardial tissue characterization. The purpose of this pilot study was to assess the feasibility of measuring in-vivo stiffness changes in infarcted tissue and compare with remote (i.e. non-infarcted) myocardium in the same pig using 3D MRE. Results indicate a 3-fold increase in stiffness of the infarct compared to the normal myocardium.

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