Shivaram Poigai Arunachalam1, Arvin Arani1, Francis Baffour1, Joseph Rysavy2, Phillip Rossman1, David Lake3, Kevin Glaser1, Joshua Trzasko1, Armando Manduca3, Kiaran McGee1, Richard Ehman1, and Philip Araoz1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Surgery, Mayo Clinic, Rochester, MN, United States, 3Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States
Myocardial stiffness is a novel biomarker with both
diagnostic and prognostic potential for a range of cardiac diseases such as
myocardial infarction which is known to significantly increase stiffness. Magnetic Resonance Elastography (MRE) is
a non-invasive imaging technique that
can be applied to the heart for in-vivo
myocardial tissue characterization. The purpose of this pilot study was to assess the
feasibility of measuring in-vivo
stiffness changes in infarcted tissue and compare with remote (i.e.
non-infarcted) myocardium in the same pig using 3D MRE. Results indicate a 3-fold increase in
stiffness of the infarct compared to the normal myocardium.