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Abstract #2542

Accelerated Multi-contrast Late Enhancement with Isotropic Spatial Resolution Using Compressed Sensing with Edge Preservation for Improved Characterization of Infarct Heterogeneity: Initial Clinical Experience

Li Zhang1,2, Mihaela Pop1,2, and Graham A Wright1,2

1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Accurate characterization of infarct heterogeneity depends on high spatial resolution imaging1. This study was performed to evaluate the use of an accelerated multi-contrast late enhancement acquisition (MCLE)2 with COmpressed Sensing with Edge Preservation (COSEP) for isotropic spatial resolution imaging to improve characterization of infarct heterogeneity in the clinical setting. We have shown that an isotropic resolution of 2.2mm could be achieved using an accelerated three-dimensional (3D) MCLE acquisition within a single breath-hold in a patient study and the COSEP reconstruction provides improved characterization of infarct heterogeneity compared to an alternative compressed sensing method.

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