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Abstract #2543

Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study

Antonella Meloni1, Nicola Giunta2, Pietro Giuliano2, Maria Giovanna Neri1, Stefania Renne3, Antonino Vallone4, Massimiliano Missere5, Emanuele Grassedonio6, Vincenzo Positano1, Daniele De Marchi1, and Alessia Pepe1

1Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, 2"ARNAS" Civico, Palermo, Italy, 3P.O. “Giovanni Paolo II”, Lamezia Terme (CZ), Italy, 4Az. Osp. "Garibaldi" Presidio Ospedaliero Nesima, Catania, Italy, 5P.O. “Giovanni Paolo II”, Campobasso, Italy, 6Policlinico "Paolo Giaccone", Palermo, Italy

We prospectively assessed the predictive value of MRI for cardiac complications in talassemia intermedia (TI). All our patients underwent MRI examination assessing multi-parametric findings (heart and liver iron, myocardial fibrosis, atrial areas, and biventricular function).

Righ ventricular (RV) hypertrophy identified patients at high risk for arrhythmias and pulmonary hypertension. Both RV hypertrophy and fibrosis detected by LGE were independent predictive factor for cardiac complications. So, a widespread program using MRI exploiting its multi-parametric potential, including the measurement of RV mass, can have considerable power for opening the prognosis of TI patients by the early identification and treatment of patients at risk for cardiac complications.

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