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Abstract #2544

Microvascular obstruction and hemorrhage influence T1 and T2 relaxation parameters in the detection of edema in acute myocardial infarction

Nilesh R. Ghugre1,2,3, Venkat Ramanan1, Jing Yang1, Idan Roifman3, Mohammad I Zia3, Bradley H Strauss3, Kim A Connelly4, and Graham A Wright1,2,3

1Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Schulich Heart Research Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4Cardiology, St. Michaels Hospital, Toronto, ON, Canada

T1 and T2 relaxation parameters have been instrumental in quantifying both edema and hemorrhage in acute myocardial infarction (AMI). Unlike T2, the combined effect of edema and hemorrhage on T1 has not been well described. Our study assessed and compared the impact of microvascular obstruction (MVO) and hemorrhage on the sensitivity of T1 and T2 in the quantification of edema. Our study indicated that the capacity of T1 to detect edema is affected by the counteracting influence from hemorrhage. Furthermore, T2 may be more sensitive to edema than T1 in AMI, particularly in the presence of MVO and hemorrhage.

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