Abstract #2549

Combined High Resolution, Four Dimensional, CE-MRA and DCE-MRI of Carotid Atherosclerotic Plaque

Jianmin Yuan¹, Andrew J Patterson², Ammara Usman¹, Gregory C Makris¹, Zhongzhao Teng¹, Jonathan H Gillard¹, and Martin J Graves^1,2

¹Department of Radiology, University of Cambridge, Cambridge, United Kingdom, ²Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom

Carotid neovascularization and lumen surface morphology both play important roles in the progression of atherosclerotic plaque. This study uses a high-spatial and temporal resolution dynamic 3D contrast-enhanced (CE) imaging technique to simultaneously acquire and explore the relationship between the two factors. Results demonstrate that carotid luminal stenosis and appearance of ulceration are correlated with the plaque neovascularization. The study shows the ability to perform high-resolution carotid plaque morphology and functional assessment within a reasonable scanning time.

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