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Abstract #2550

Accumulation of Atherosclerotic Plaque in Mouse Aortic Valves Determined by MRI

Hanne Hakkarainen1, Jaana Rysä2, Anna-Kaisa Ruotsalainen1, Anna-Liisa Levonen1, and Timo Liimatainen1,3

1A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 2School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 3Imaging Center, Kuopio University Hospital, Kuopio, Finland

High resolution cine-MRI was applied for examining aortic valve function and atherosclerotic plaque accumulation in the valves in mice on a high fat diet. The end systolic images of the aortic valves of these mice showed clear signs of atherosclerotic fat accumulation and dysfunction of the valves. This implies that the cine-MRI method provides a noninvasive tool for monitoring atherosclerotic plaques in the mouse aortic valves.

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