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Abstract #2551

Feasibility of 3D multi-sequence PET/MRI of carotid atherosclerosis

Rik PM Moonen1, Stefan Vöö2, Jan Bucerius2, Joachim Wildberger1, and Eline Kooi1

1Department of Radiology, Maastricht University Medical Center +, Maastricht, Netherlands, 2Department of Nuclear Medicine, Maastricht University Medical Center +, Maastricht, Netherlands

Noninvasive imaging can improve risk stratification in carotid atherosclerosis. Multi-sequence MRI allows visualization of plaque burden and components, while PET can be used to study inflammation. Combining the two modalities with hybrid PET/MRI in a one-stop shop approach may improve assessment of vulnerable plaque.

The goal of this work was to optimize a 3D multi-sequence carotic PET/MRI protocol including 3D MPRAGE, 3D SPACE pre- and post-contrast, and UTE, using simulations and optimization in healthy volunteers.

Feasibility of the protocol was demonstrated in a patient suffering from carotid atherosclerosis (>70% stenosis).

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