Abstract #2559

A simulation study and application of UTE-ΔR2-ΔR2* combined MR whole brain angiogram using dual contrast superparamagnetic iron oxide nanoparticles.

HoeSu Jung¹, SeokHa Jin¹, DongKyu Lee¹, SoHyun Han¹, and HyungJoon Cho¹

¹Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of

Transverse-relaxation-based ΔR₂- and ΔR₂^*- micro MRAs are being investigated for imaging cerebral vasculature in rodent brains with increased sensitivity for intracortical arterioles and venules, in conjunction with exogenous blood pool contrast agents. In this study, we simulated extravascular signal decay behaviors of ΔR₂, and ΔR₂^* values for multiple cylindrical models with varying diameters to quantitatively assess both sensitivity and size overestimation issues in micro MRA. The benefits of following synergistic combination of ΔR₂, and ΔR₂^* angiograms along with the UTE-derived positive angiogram were investigated, and corresponding UTE-ΔR₂-ΔR₂^* combined angiogram was applied to normal and C6 glioma tumor model for the verifications.

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