Abstract #2560

Optimization of high resolution contrast-enhanced magnetic resonance angiography via modulation transfer function analysis

Toshimasa James Clark¹, Gregory J Wilson², and Jeffrey H Maki²

¹Department of Radiology, University of Colorado Denver, Aurora, CO, United States, ²Department of Radiology, University of Washington, Seattle, WA, United States

CE-MRA spatial resolution is determined by a complex interaction between acquired voxel size, gadolinium injection rate, contrast volume, cardiac output, magnetic field strength, and acquisition duration. R1 relaxivity non-linearity and R2* signal degradation inherent in SPGR acquisitions play important roles in observed signal intensity during bolus passage. Through generation of modulation transfer functions spanning the gamut of parameter values likely to be seen in clinical practice we derive injection rates that produce optimal image contrast and resolution in our model.

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