Abstract #2561

Flip-Angle and dose optimization in Ferumoxytol-enhanced MRA: Preliminary results compared with Gadolinium-enhanced MRA.

Tilman Schubert^1,2, Utaroh Motosugi³, Samir Sharma⁴, Sonja Kinner¹, Shane Wells¹, Diego Hernando¹, and Scott Reeder¹

¹Radiology, University of Wisconsin Madison, Madison, WI, United States, ²Clinic for Radiology and Nuclear Medicine, Basel University Hospital, Basel, Switzerland, ³Department of Radiology, University of Yamanashi, Yamanashi, Japan, ⁴Medical Physics, University of Wisconsin Madison, Madison, WI, United States

Ferumoxytol has gained interest as a positive MR-contrast agent in patients with renal failure. However, limited data exist regarding the optimal/minimal dose for MRA applications and optimal scanning parameters. Therefore, this study evaluated image quality with different doses of ferumoxytol with gadolinium as reference. Furthermore, flip angle optimization was performed in the steady state. Relative SNR was found to be significantly higher for gadolinium- compared to ferumoxytol-enhanced MRA during first pass. However, this did not lead to qualitative penalty for ferumoxytol-enhanced MRA. Flip angle-optimization indicated that adapting the flip angle to dose may help to achieve optimal results.

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