Meeting Banner
Abstract #2561

Flip-Angle and dose optimization in Ferumoxytol-enhanced MRA: Preliminary results compared with Gadolinium-enhanced MRA.

Tilman Schubert1,2, Utaroh Motosugi3, Samir Sharma4, Sonja Kinner1, Shane Wells1, Diego Hernando1, and Scott Reeder1

1Radiology, University of Wisconsin Madison, Madison, WI, United States, 2Clinic for Radiology and Nuclear Medicine, Basel University Hospital, Basel, Switzerland, 3Department of Radiology, University of Yamanashi, Yamanashi, Japan, 4Medical Physics, University of Wisconsin Madison, Madison, WI, United States

Ferumoxytol has gained interest as a positive MR-contrast agent in patients with renal failure. However, limited data exist regarding the optimal/minimal dose for MRA applications and optimal scanning parameters. Therefore, this study evaluated image quality with different doses of ferumoxytol with gadolinium as reference. Furthermore, flip angle optimization was performed in the steady state. Relative SNR was found to be significantly higher for gadolinium- compared to ferumoxytol-enhanced MRA during first pass. However, this did not lead to qualitative penalty for ferumoxytol-enhanced MRA. Flip angle-optimization indicated that adapting the flip angle to dose may help to achieve optimal results.

This abstract and the presentation materials are available to members only; a login is required.

Join Here