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Abstract #2642

Assessment of R1 Relaxation Rate Error in DCE-MRI Using Bookend Measurements

Michael Josef Dubec1 and Lucy Elizabeth Kershaw1,2

1CMPE, The Christie NHS Foundation Trust, Manchester, United Kingdom, 2Institute of Cancer Sciences, University Of Manchester, Manchester, United Kingdom

Dynamic contrast enhanced MRI (DCE-MRI) allows quantitative assessment of tumour status. The addition of a relaxation rate (R1) measurement following the dynamic acquisition in DCE-MRI studies allows the uncertainty in the conversion from signal intensity (S) to R1 to be assessed. In this work the effect of errors in flip angle and pre-contrast signal estimation on the S(t) to R1(t) conversion were evaluated. Results indicated that uncertainty in the measurement of Spre had greater effect than realistic flip angle variations on the S(t) to R1(t) conversion, and that the error was tissue dependent.

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