Abstract #2642

Assessment of R1 Relaxation Rate Error in DCE-MRI Using Bookend Measurements

Michael Josef Dubec¹ and Lucy Elizabeth Kershaw^1,2

¹CMPE, The Christie NHS Foundation Trust, Manchester, United Kingdom, ²Institute of Cancer Sciences, University Of Manchester, Manchester, United Kingdom

Dynamic contrast enhanced MRI (DCE-MRI) allows quantitative assessment of tumour status. The addition of a relaxation rate (R₁) measurement following the dynamic acquisition in DCE-MRI studies allows the uncertainty in the conversion from signal intensity (S) to R₁ to be assessed. In this work the effect of errors in flip angle and pre-contrast signal estimation on the S(t) to R₁(t) conversion were evaluated. Results indicated that uncertainty in the measurement of S_pre had greater effect than realistic flip angle variations on the S(t) to R₁(t) conversion, and that the error was tissue dependent.

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