Abstract #2643

Spatial Overlapping between the Subvolumes with Elevated CBV and with Hypercellularity in Glioblastoma

Hemant Parmar¹, Daniel Wahl², Priyanka Pramanik², Michelle Kim², Theodore S Lawrence², and Yue Cao^1,2

¹Radiology, University of Michigan, Ann Arbor, MI, United States, ²Radiation Oncology, University of Michigan, Ann Arbor, MI, United States

Standard imaging for glioblastoma relies on post-contrast T1 and T2 FLAIR MRI sequences, which do not accurately reflect tumor biology. Advanced MRI techniques can define biologically relevant and prognostic features of glioblastoma including perfusion-based volumes with high cerebral blood volume (V_hCBV) and high b-value diffusion-based hypercellular subvolume (HCV). We defined V_hCBV and HCV in 24 patients with glioblastoma prior to undergoing chemoradiation. Surprisingly, there was little overlap between V_hCBV and HCV within individual patients, which suggests that these volumes represent distinct aspects of tumor biology and may be independently prognostic. Analysis of failure patterns and prognostic relevance is ongoing.

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