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Abstract #2644

Ultrahigh-field (9.4T and 17.6T) magnetic resonance imaging of retinoblastoma: ex vivo evaluation of microstructural anatomy and disease extent

Marcus Christiaan de Jong1, Pim de Graaf1, Petra Pouwels1, Jan-Willem Beenakker2, Jeroen Geurts1, Annette C. Moll1, Jonas A. Castelijns1, Paul van der Valk1, and Louise van der Weerd2

1VU University Medical Center, Amsterdam, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands

Staging of retinoblastoma – the most common pediatric eye cancer – is currently performed in vivo at 1.5 or 3.0 T and allows for images with voxel sizes <0.5x0.5x2 mm3. We performed ex vivo ultrahigh-resolution MRI at 9.4 and 17.6 T of enucleated retinoblastoma eyes. This method allowed us to generate high-resolution images (voxel size: 59x59x59 to 100x100x100 μm3) of different aspects of retinoblastoma showing the potential of ultrahigh-resolution MRI for staging retinoblastoma and gaining insight in anatomical details.

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