Abstract #2644

Ultrahigh-field (9.4T and 17.6T) magnetic resonance imaging of retinoblastoma: ex vivo evaluation of microstructural anatomy and disease extent

Marcus Christiaan de Jong¹, Pim de Graaf¹, Petra Pouwels¹, Jan-Willem Beenakker², Jeroen Geurts¹, Annette C. Moll¹, Jonas A. Castelijns¹, Paul van der Valk¹, and Louise van der Weerd²

¹VU University Medical Center, Amsterdam, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands

Staging of retinoblastoma – the most common pediatric eye cancer – is currently performed in vivo at 1.5 or 3.0 T and allows for images with voxel sizes <0.5x0.5x2 mm³. We performed ex vivo ultrahigh-resolution MRI at 9.4 and 17.6 T of enucleated retinoblastoma eyes. This method allowed us to generate high-resolution images (voxel size: 59x59x59 to 100x100x100 μm³) of different aspects of retinoblastoma showing the potential of ultrahigh-resolution MRI for staging retinoblastoma and gaining insight in anatomical details.

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