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Abstract #2668

Motion Insensitive 3D technique for simultaneous measurement of in-vivo ADC and T2* in Atherosclerotic plaque using a 3D Multiple Echo Diffusion Weighted Driven Equilibrium Stack of Stars (3D ME-DW-DE SOS) Sequence.

Seong-Eun Kim1, J Scott McNally1, Bradley D Bolster, Jr.2, Gerald S Treimam3,4, and Dennis L Parker 1

1Department of Radiology, UCAIR, University of Utah, Salt Lake City, UT, United States, 2Siemens Healthcare, Salt Lake City, UT, United States, 3Department of Surgery, University of Utah, Salt Lake City, UT, United States, 4Department of Veterans Affairs, VASLCHCS, Salt Lake City, UT, United States

DWI has the potential to provide complementary information that will allow better discrimination of plaque components such as lipid core. Iron has consistently been found in higher concentrations in atherosclerotic plaque compared to vessel tissue. In previous studies, intraplaque T2* distinguished symptomatic from asymptomatic plaques in patients with carotid atherosclerosis. In this work we introduce simultaneous measurement of ADC and T2* using a motion insensitive high resolution 3D multiple echo diffusion weighted driven equilibrium Stack of Stars sequence. This technique can provide high resolution T2* and ADC values simultaneously, which may provide important clinical information to detect plaque progression.

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