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Abstract #2674

Preliminary evaluation of Respiratory Self Navigated Whole-Heart Angiography in Combination with Ultra-small Super-paramagnetic Iron Oxide Particles

Davide Piccini1,2, Peter J. Weale3, Saeed Mirsadraee4, Rachel O. Forsythe5, Annette S. Cooper6, and Scott Semple5,6

1Advanced Clinical Imaging Technology, Siemens Healthcare, Lausanne, Switzerland, 2Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 3Siemens Healthcare Ltd, Camberley, United Kingdom, 4NHS Lothian & Clinical Research Imaging Centre Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom, 5Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom, 6Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom

Respiratory self-navigated 3D-radial MRA is an efficient and robust method for the depiction of coronary luminal anatomy at 1.5T. Higher magnetic fields are more challenging, due to off-resonance artifacts. Contrast-enhanced imaging is usually beneficial. However, variable contrast during prolonged scans can deteriorate the self-navigation signal. Here we investigate the use of an ultra-small super-paramagnetic iron oxide particles (USPIO) contrast agent with longer half-life in combination with self-navigation at 3T. Systolic and diastolic datasets from 10 volunteers were acquired and analyzed. We show that USPIO contrast-enhanced self-navigated coronary MRA is feasible at 3T with good image quality and reliable motion correction.

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