Abstract #2674

Preliminary evaluation of Respiratory Self Navigated Whole-Heart Angiography in Combination with Ultra-small Super-paramagnetic Iron Oxide Particles

Davide Piccini^1,2, Peter J. Weale³, Saeed Mirsadraee⁴, Rachel O. Forsythe⁵, Annette S. Cooper⁶, and Scott Semple^5,6

¹Advanced Clinical Imaging Technology, Siemens Healthcare, Lausanne, Switzerland, ²Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ³Siemens Healthcare Ltd, Camberley, United Kingdom, ⁴NHS Lothian & Clinical Research Imaging Centre Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom, ⁵Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom, ⁶Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom

Respiratory self-navigated 3D-radial MRA is an efficient and robust method for the depiction of coronary luminal anatomy at 1.5T. Higher magnetic fields are more challenging, due to off-resonance artifacts. Contrast-enhanced imaging is usually beneficial. However, variable contrast during prolonged scans can deteriorate the self-navigation signal. Here we investigate the use of an ultra-small super-paramagnetic iron oxide particles (USPIO) contrast agent with longer half-life in combination with self-navigation at 3T. Systolic and diastolic datasets from 10 volunteers were acquired and analyzed. We show that USPIO contrast-enhanced self-navigated coronary MRA is feasible at 3T with good image quality and reliable motion correction.

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