Abstract #2679

Intra-individual quantitative and qualitative comparison of 4D-MRA- and dynamic CTA-bolus-time-curves of gadopentetate dimeglumine and gadobutrol in minipigs

Dariusch Reza Hadizadeh¹, Vera Catharina Keil¹, Gregor Jost², Hubertus Pietsch², Martin Weibrecht³, Bishr Agha¹, Christian Marx¹, Michael Perkuhn³, Hans Heinz Schild¹, and Winfried Albert Willinek⁴

¹Radiology, University of Bonn, Bonn, Germany, ²MR and CT Contrast Media Research, Bayer Healthcare, Berlin, Germany, ³Innovative Technologies, Research Laboratories, Philips Technologie GmbH, Aachen, Germany, ⁴Department of Radiology, Neuroradiology, Sonography and Nuclear Medicine, Brüderkrankenhaus Trier, Trier, Germany

In an animal model bolus kinetics and image quality after injection of 1M gadobutrol (standard and half-dose) and 0.5M gadopentetate dimeglumine (standard-dose) had been investigated in 4D-MRA at 3T and dynamic CTA. The first pass arterial peak Gd-concentrations (quantified by CTA) were higher for standard-dose compared to half-dose gadobutrol. In 4D-MRA the first pass arterial peak enhancement was comparable for both gadobutrol doses and gadopentetate dimeglumine due to peak cut-off effects at high vascular Gd concentrations. Markedly higher venous bolus peaks were found for standard-dose gadobutrol. Image quality of 4D-MRA was rated significantly higher for both doses of gadobutrol.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.