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Abstract #2679

Intra-individual quantitative and qualitative comparison of 4D-MRA- and dynamic CTA-bolus-time-curves of gadopentetate dimeglumine and gadobutrol in minipigs

Dariusch Reza Hadizadeh1, Vera Catharina Keil1, Gregor Jost2, Hubertus Pietsch2, Martin Weibrecht3, Bishr Agha1, Christian Marx1, Michael Perkuhn3, Hans Heinz Schild1, and Winfried Albert Willinek4

1Radiology, University of Bonn, Bonn, Germany, 2MR and CT Contrast Media Research, Bayer Healthcare, Berlin, Germany, 3Innovative Technologies, Research Laboratories, Philips Technologie GmbH, Aachen, Germany, 4Department of Radiology, Neuroradiology, Sonography and Nuclear Medicine, Br├╝derkrankenhaus Trier, Trier, Germany

In an animal model bolus kinetics and image quality after injection of 1M gadobutrol (standard and half-dose) and 0.5M gadopentetate dimeglumine (standard-dose) had been investigated in 4D-MRA at 3T and dynamic CTA. The first pass arterial peak Gd-concentrations (quantified by CTA) were higher for standard-dose compared to half-dose gadobutrol. In 4D-MRA the first pass arterial peak enhancement was comparable for both gadobutrol doses and gadopentetate dimeglumine due to peak cut-off effects at high vascular Gd concentrations. Markedly higher venous bolus peaks were found for standard-dose gadobutrol. Image quality of 4D-MRA was rated significantly higher for both doses of gadobutrol.

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