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Abstract #2681

Evaluation of Dual Agent Relaxation Contrast MR Lymphangiography (DARC-MRL) for Pre-surgical Identification of Lymphatic Channels

Beth Ripley1, Gregory J Wilson1, and Jeffrey H Maki1

1Department of Radiology, University of Washington Medical Center, Seattle, WA, United States

A new method of lymphatic channel mapping was evaluated in a retrospective review of pre-surgical lymphedema MR exams. Dual Agent Relaxation Contrast MR Lymphangiography (DARC-MRL) uses intracutaneous injection of a Gd contrast agent for enhancement of lymphatic channels and concomitant intravenous injection of USPIO (ferumoxytol) for suppression of (otherwise lymphatic-obscuring) veins. 43 MR exams using DARC-MRL were compared to 43 matched exams using conventional (no USPIO) MR lymphangiography. Exams were graded for degree of venous contamination, and DARC-MRL exams exhibited dramatically less obscuring venous contamination than the conventional method.

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