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Abstract #2723

Pre-treatment DCE-MRI based tumour heterogeneity is associated with traditional prognostic parameters and provides an insight into early recurrence following neoadjuvant chemotherapy in locally advanced breast cancer

Martin D Pickles1, Martin Lowry1, and Peter Gibbs1

1Centre for Magnetic Resonance Investigations, Hull York Medical School at University of Hull, Hull, United Kingdom

Tumours can have high levels of heterogeneity. Lesions demonstrating high levels of heterogeneity have an ‘aggressive’ phenotype. Assessing heterogeneity might provide superior insights into treatment response than traditional mean/median values. The aims of this study were to determine if histogram analysis of pre-treatment DCE-MRI parameters are associated with traditional prognostic indicators and early breast cancer recurrence.

Breast dynamic datasets from 208 individuals underwent histogram analysis. U-tests and survival analysis indicated that DCE-MRI histogram parameters are associated with traditional prognostic indicators, have superior prognostic information than mean/median values and provide independent prognostic information regarding breast cancer recurrence prior to therapy initiation.

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