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Abstract #2724

Amide proton transfer (APT) imaging of breast cancer at 3T MRI: a pilot study

Natsuko Onishi1, Masako Kataoka1, Shotaro Kanao1, Mami Iima1, Makiko Kawai1, Akane Ohashi1, Katsutoshi Murata2, Benjamin Schmitt3, and Kaori Togashi1

1Dept of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Research & Collaboration Dpt., Siemens Japan K.K., Tokyo, Japan, 3Healthcare Sector, Siemens Ltd, Melbourne, Australia

Amide proton transfer (APT) imaging is the representative endogenous chemical exchange saturation transfer (CEST) imaging that has been applied to some clinical cancer studies. However, little is known about the clinical usefulness of APT imaging in breast cancer. In this study, 3T MRI studies including APT imaging were performed for 24 breast cancer lesions, and the possible utility of APT imaging in evaluating biochemical information induced by breast cancer was demonstrated. APT CEST imaging is a potentially useful MRI technique for breast cancer.

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