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Abstract #2726

Distinguishing pure ductal carcinoma in situ grade using quantitative DWI biomarkers at 3 Tesla

Jing Yuan1, Gladys Lo2, Oilei Wong1, Helen H.L. Chan2, Ting Ting Wong3, and Polly S.Y. Cheung3

1Medical Physics and Research Department, Hong Kong Sanatorium&Hospital, Hong Kong, Hong Kong, 2Department of Diagnostic & Interventional Radiology, Hong Kong Sanatorium&Hospital, Hong Kong, Hong Kong, 3Breast Care Center, Hong Kong Sanatorium&Hospital, Hong Kong, Hong Kong

This study aims to explore the use of quantitative breast DWI at 3T to distinguish DCIS pathological grades. In a cohort of 30 pathology confirmed pure DCIS, the mean ADC was 1.26±0.19, 1.51±0.29 and 1.13±0.26 x10-3 mm2/s for low (n=5), intermediate (n=9) and high-grade (n=16) DCIS respectively. The high-grade DCIS could be distinguished by the significantly lower mean ADC from non-high grade DCIS (low and intermediate grades, 1.42±0.28 x10-3 mm2/s, p=0.0057). Quantitative DWI has potentials to aid DCIS risk stratification and management.

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