Abstract #2727

MRI Biomarkers of breast cancer complete pathologic response to neoadjuvant chemotherapy

Elizabeth Jane Sutton¹, Duc A. Fehr², Brittany Z. Dashevsky^1,3, Sunitha B Thakur², Joseph O. Deasy², Elizabeth A Morris¹, and Harini Veeraraghavan²

¹Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ³Radiology, University of Chicago, Chicago, IL, United States

Neoadjuvant chemotherapy (NAC) is used in breast cancer and pathologic complete response (pCR) is associated with improved survival. Computer extracted MRI features generate quantitative metrics of treatment response. We used an interactive Grow-Cut method to volumetrically segment breast cancers on multiparametric breast MRI pre and post NAC and then computed Haralick features for each sequence. We found a difference in the MRI tumor texture features pre and post NAC. We also found this difference to be statistically significant between tumors with pCR and no-pCR. These metrics demonstrate changes in tumor microenvironment post NAC and are biomarkers for pCR.

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