Abstract #2729

Triexponential Diffusion Analysis in Breast Cancer

Masako Ohno¹, Tosiaki Miyati², Naoki Ohno², Hiroko Kawashima², Kazuto Kozaka¹, Yukihiro Matsuura¹, and Toshifumi Gabata¹

¹Kanazawa University Hospital, Kanazawa, Japan, ²Kanazawa University, Kanazawa, Japan

To acquire more detailed information on perfusion and diffusion in breast cancer, we analyzed three diffusion components using triexponential function. Perfusion-related diffusion (D_p), fast free diffusion (D_f), and slow restricted diffusion coefficients (D_s) were calculated from triexponential function. We compared these parameters between invasive ductal carcinoma (IDC) and ductal carcinoma in situ (DCIS) groups. D_s was significantly lower in the IDC group than those in the DCIS group because of difference in the cellularity. Triexponential analysis makes it possible to noninvasively obtain more detailed information on perfusion and diffusion in breast cancer, thereby assisting in the diagnosis.

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