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Abstract #2736

Quantitative magnetic resonance imaging of lymphatic function before and after manual lymphatic drainage in patients with breast cancer treatment-related lymphedema

Paula M.C. Donahue1, Allison O. Scott2, Rachelle Crescenzi2, Aditi Desai2, Vaughn Braxton2, and Manus J. Donahue2

1Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, United States, 2Radiology, Vanderbilt University Medical Center, Nashville, TN, United States

The overall goal of this work is to develop quantitative biomarkers of lymphatic system structure and function using noninvasive 3T MRI. Here, we focus on breast cancer treatment-related lymphedema (BCRL) where we hypothesize quantitative T2 is elevated in patients relative to controls resulting from greater fluid content in the region of interests, and which reduces following manual lymphatic drainage (a commonly performed therapy intervention). Findings suggest abilities to detect changes consistent with intervention-elicited lymphatic dynamics by using internal measures of tissue composition from MRI otherwise not detected using more common limb volume, bioimpedance spectroscopy and tissue dielectric constant measures.

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