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Abstract #2735

Comparisons of pre- and post-treatment intravoxel incoherent motion (IVIM) biomarkers to clinical response in breast cancer patients undergoing neoadjuvant treatment

Gene Young Cho1,2,3, Lucas Gennaro2, Elizabeth J Sutton2, Emily C Zabor2, Zhigang Zhang2, Linda Moy1, Daniel K Sodickson1, Elizabeth A Morris2, Eric E Sigmund1, and Sunitha B Thakur2

1Department of Radiology, Center for Advanced Imaging Innovation and Research (CAI2R) and Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States, 2Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3The Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY, United States

Using the intravoxel incoherent motion (IVIM) effect, one can characterize the tumor microenvironment in terms of vascularity and cellularity. Combined with histogram analysis of these IVIM biomarkers, these metrics are compared to clinical responders and nonresponders of neoadjuvent treatment (NAT) in breast cancer patients. We examine the prognostic capabilities of these IVIM metrics and find that (1) certain IVIM parameters significantly differentiate between responders and nonresponders to NAT and (2) IVIM parameters change between pre- and post-treatment MRI scans. This data shows IVIM MRI to be a potentially powerful prognostic tool in breast cancer.

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