Abstract #2734

Detecting BOLD vasomotor contrast in healthy breast parenchyma and breast carcinoma

Tess E. Wallace¹, Andrew J. Patterson², Oshaani Abeyakoon¹, Reem Bedair¹, Roie Manavaki¹, Mary A. McLean³, James P. B. O'Connor⁴, Martin J. Graves², and Fiona J. Gilbert¹

¹Department of Radiology, University of Cambridge, Cambridge, United Kingdom, ²Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, ³Cancer Research UK Cambridge Institute, Cambridge, United Kingdom, ⁴Institute of Cancer Sciences, University of Manchester, Manchester, United Kingdom

Blood oxygenation level-dependent (BOLD) MRI with hyperoxic/hypercapnic gas stimuli has potential to non-invasively probe vascular function, which could help characterize tumors, predict treatment susceptibility and monitor response. This work evaluates BOLD contrast changes in healthy breast parenchyma in response to air and oxygen interleaved with 2% and 5% carbogen gas mixtures, relative to an all-air control. We found that oxygen vs. 5% carbogen was the most robust stimulus for inducing BOLD contrast in the breast. Measurements may be confounded by physiological fluctuations and menstrual cycle changes. Response in breast carcinoma was variable and may indicate underlying differences in vascular function.

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