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Abstract #2747

Comparison of performance of quantitative ADC versus PI-RADS v2 assessment for differentiating high-grade from low-grade prostate cancer

Elmira Hassanzadeh1, Olutayo I Olubiyi1, Andriy Fedorov 1, Daniel I Glazer1, Clare M Tempany1, and Fiona M Fennessy1,2

1Brigham and Women's Hospital, Boston, MA, United States, 2Dana-Farber Cancer Institute, Boston, MA, United States

One of the challenges in prostate cancer (PCa) management is the ability to differentiate aggressive tumors that require prompt treatment from indolent tumors that can safely undergo active surveillance. To promote global standardization and diminish variation in the acquisition, interpretation, and reporting of prostate multi-parametric MRI (mpMRI) examinations, Prostate Imaging Reporting and Data System (PI-RADS) has been introduced. The second version of PI-RADS (PI-RADS v2) was released early in 2015, but requires clinical validation. Here, we present the results of a study investigating the performance of PI-RADS v2 compared to quantitative ADC (qADC) values in discriminate high-grade from low-grade PCa.

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