Rajakumar Nagarajan1, Zohaib Iqbal1, Neil Wilson1, Daniel J Margolis1, Steven S Raman1, Robert E Reiter2, and M.Albert Thomas1
1Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, 2Urology, University of California Los Angeles, Los Angeles, CA, United States
Prostate cancer (PCa) is the second leading cause of cancer
related death in Western countries. Conventional 3D MRSI in PCa using weighted
encoding and long echo time. One dimensional MRSI suffers from overlapping of
metabolites. In this study, a non-uniformly undersampled (NUS) five dimensional
(5D) echo planar J-Resolved spectroscopic imaging (EP-JRESI) sequence using semi
LASER radio-frequency pulses for optimal refocusing was used to record 2D
J-resolved spectra from multiple prostate locations and to quantify changes in
prostate metabolites, Cit, Cr, Ch and mI after compressed sensing
reconstruction of the NUS 5D EP-JRESI data by minimizing total variation
method. Also, we found the prostate
metabolites ratios (Ch+Cr/Cit and Ch+Cr/mI) were inversely correlated with ADC
values.
