Abstract #2755

Prostate Cancer Detection Using Accelerated 5D EPJRESI - sLASER Combined With DWI

Rajakumar Nagarajan¹, Zohaib Iqbal¹, Neil Wilson¹, Daniel J Margolis¹, Steven S Raman¹, Robert E Reiter², and M.Albert Thomas¹

¹Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ²Urology, University of California Los Angeles, Los Angeles, CA, United States

Prostate cancer (PCa) is the second leading cause of cancer related death in Western countries. Conventional 3D MRSI in PCa using weighted encoding and long echo time. One dimensional MRSI suffers from overlapping of metabolites. In this study, a non-uniformly undersampled (NUS) five dimensional (5D) echo planar J-Resolved spectroscopic imaging (EP-JRESI) sequence using semi LASER radio-frequency pulses for optimal refocusing was used to record 2D J-resolved spectra from multiple prostate locations and to quantify changes in prostate metabolites, Cit, Cr, Ch and mI after compressed sensing reconstruction of the NUS 5D EP-JRESI data by minimizing total variation method. Also, we found the prostate metabolites ratios (Ch+Cr/Cit and Ch+Cr/mI) were inversely correlated with ADC values.

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