Abstract #2756

Prostate tumor growth in patients on active surveillance: is a change in the apparent diffusion coefficient an indicator of an accelerated growth rate?

Veronica A Morgan^1,2, Chris Parker³, and Nandita M deSouza^1,2

¹MRI, Royal Marsden Hospital, Sutton, United Kingdom, ²Clinical Magnetic Resonance Unit, Institute of Cancer Research, London, United Kingdom, ³Urology, Royal Marsden Hospital, Sutton, United Kingdom

We evaluated relationship between tumor doubling time and ADC in prostate cancer patients managed by active surveillance. Tumor (defined as a low signal-intensity T2-W region showing restricted diffusion and a Type3 contrast-enhanced curve within a biopsy positive octant) volume was calculated at 3 time-points ~12-24mths apart in 22 patients by drawing regions-of-interest on the T2-W images. Mean tumor ADC was estimated centrally through the tumor. Five of 22 tumors (22.7%) showed growth acceleration after the second time-point. A 10% decrease in ADC identified 3 of 4 tumors and missed 1 of 22 cases with a doubling time of <12 months.

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