Mihaela Rata1, Monica Celli2, Veronica Morgan1, Geoffrey Payne1, Jonathan Gear2, Emma Alexander1, Sue Chua2, David Dearnaley1, and Nandita deSouza1
1Radiotherapy and Imaging, CR-UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden Hospital, London, United Kingdom, 2Department of Nuclear Medicine and PET/CT, Royal Marsden Hospital, Sutton, United Kingdom
Intracellular
choline, a putative marker of prostate cancer, may be measured using 1H-MRS,
while uptake of extrinsic radiolabelled choline derivatives (11C-choline
and 18F-choline) on PET is used to identify prostate cancer. We
compared the steady-state concentrations of total choline (1H-MRS)
with the uptake of 18F-Choline on PET in a cohort of 11 prostate
cancer patients. The
measured choline/water ratio in tumor was 0.09±0.02 x10-3 units; the normalized
18F-Choline
uptake was 2.69±1.There
was a weak negative correlation between measured MRS and early PET uptake
(-0.61, p=0.04)
suggesting an increased
avidity of prostate tumors for choline when internal concentrations are low.
