Abstract #2757

Choline metabolism in prostate cancer: relationship between 1H-MRS measured concentrations and uptake of 18F-Choline on PET-CT in the dominant tumor nodule

Mihaela Rata¹, Monica Celli², Veronica Morgan¹, Geoffrey Payne¹, Jonathan Gear², Emma Alexander¹, Sue Chua², David Dearnaley¹, and Nandita deSouza¹

¹Radiotherapy and Imaging, CR-UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden Hospital, London, United Kingdom, ²Department of Nuclear Medicine and PET/CT, Royal Marsden Hospital, Sutton, United Kingdom

Intracellular choline, a putative marker of prostate cancer, may be measured using ¹H-MRS, while uptake of extrinsic radiolabelled choline derivatives (¹¹C-choline and ¹⁸F-choline) on PET is used to identify prostate cancer. We compared the steady-state concentrations of total choline (¹H-MRS) with the uptake of ¹⁸F-Choline on PET in a cohort of 11 prostate cancer patients. The measured choline/water ratio in tumor was 0.09±0.02 x10^-3 units; the normalized ¹⁸F-Choline uptake was 2.69±1.There was a weak negative correlation between measured MRS and early PET uptake (-0.61, p=0.04) suggesting an increased avidity of prostate tumors for choline when internal concentrations are low.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.