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Abstract #2757

Choline metabolism in prostate cancer: relationship between 1H-MRS measured concentrations and uptake of 18F-Choline on PET-CT in the dominant tumor nodule

Mihaela Rata1, Monica Celli2, Veronica Morgan1, Geoffrey Payne1, Jonathan Gear2, Emma Alexander1, Sue Chua2, David Dearnaley1, and Nandita deSouza1

1Radiotherapy and Imaging, CR-UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden Hospital, London, United Kingdom, 2Department of Nuclear Medicine and PET/CT, Royal Marsden Hospital, Sutton, United Kingdom

Intracellular choline, a putative marker of prostate cancer, may be measured using 1H-MRS, while uptake of extrinsic radiolabelled choline derivatives (11C-choline and 18F-choline) on PET is used to identify prostate cancer. We compared the steady-state concentrations of total choline (1H-MRS) with the uptake of 18F-Choline on PET in a cohort of 11 prostate cancer patients. The measured choline/water ratio in tumor was 0.09±0.02 x10-3 units; the normalized 18F-Choline uptake was 2.69±1.There was a weak negative correlation between measured MRS and early PET uptake (-0.61, p=0.04) suggesting an increased avidity of prostate tumors for choline when internal concentrations are low.

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