Abstract #2761

Voxel level radiologic-pathologic validation of Restriction Spectrum Imaging cellularity index with Gleason grade in Prostate Cancer

Natalie M Schenker-Ahmed¹, Ghiam Yamin¹, Ahmed Shabaik¹, Dennis Adams¹, Hauke Bartsch¹, Joshua Kuperman¹, Nathan S White¹, Rebecca A Rakow-Penner¹, Kevin McCammack¹, J Kellogg Parsons¹, Christopher Kane¹, Anders Dale¹, and David Karow¹

¹UC-San Diego, La Jolla, CA, United States

Current multiparametric magnetic resonance imaging techniques for detecting prostate cancer are limited with respect to tumor conspicuity assessment, in vivo characterization and localization. We demonstrate that a novel diffusion-based MRI technique, restriction spectrum imaging (RSI-MRI), differentiates among benign, low-grade and high-grade PCa at voxel-level resolution. Using an RSI-MRI index to differentiate between low- and high-grade categories of tumor PCa aggressiveness may help improve and refine diagnosis and staging of PCa. Additionally, because it can detect intratumor variation, RSI-MRI may have particular relevance for planning targeted therapies such as radiation seed therapy placement, MR-guided focused ultrasound surgery, and MR-guided targeted biopsy.

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