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Abstract #2762

Response of degarelix treatment in human prostate cancer monitored by HR-MAS 1H NMR spectroscopy

Basetti Madhu1, Greg Shaw1, David Neal1, and John R Griffiths1

1Molecular Imaging (MRI & MRS), Cancer Research UK Cambridge Institute, Cambridge, United Kingdom

Absolute concentrations of metabolites were measured in samples of Benign Prostate Hypertrophy (BPH) and high grade prostate cancer tissues from intact and castrate patients (Degarelix treated). Lactate, alanine, choline compounds concentrations were significantly elevated in high-grade prostate cancer biopsies when compared to BPH samples. Castration resulted in the significant decrease of lactate and t-choline concentrations in high grade prostate cancer biopsies. The reduced metabolite concentrations of lactate and t-choline observed in this study due to Degarelix shows that there is a potential application of in vivo 1H MRS to monitor non-invasively the effects of castration in prostate cancer .

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