Basetti Madhu1, Greg Shaw1, David Neal1, and John R Griffiths1
Absolute concentrations of metabolites were measured
in samples of Benign Prostate Hypertrophy (BPH) and high grade prostate cancer
tissues from intact and castrate patients (Degarelix treated). Lactate,
alanine, choline compounds concentrations were significantly elevated in
high-grade prostate cancer biopsies when compared to BPH samples. Castration
resulted in the significant decrease of lactate and t-choline concentrations in
high grade prostate cancer biopsies. The reduced metabolite concentrations of
lactate and t-choline observed in this study due to Degarelix shows that there
is a potential application of in vivo 1H MRS to monitor non-invasively the effects of
castration in prostate cancer .
