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Abstract #2768

Ethanolamine Kinase-1 as a Potential Therapeutic Biomarker in Pancreatic Cancer

Tariq Shah1, Balaji Krishnamachary1, Flonne Wildes1, Jannie Wijnen2, Kristine Glunde1, and Zaver M Bhujwalla1

1Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Utrecht, Netherlands

In understanding the aberrant choline metabolism of cancer, significant effort has been focused on phosphocholine (PC) but the role of phosphoethanolamine (PE) is relatively underexplored, even though tumors show increased PE as consistently as increased PC. Our previous findings in breast cancer cells have led us to expand our study to understand the role of ethanolamine kinase-1 (EtnK-1) and PE in pancreatic cell lines. We have demonstrated that EtnK-1 is the major contributor to PE levels in these cells and may be a potential therapeutic target.

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