Abstract #2769

Pancreatic cancer stromal characterization using diffusion tensor imaging and collagen 1 fibers in xenograft model

Samata Kakkad¹, Desmond Jacob¹, Marie-France Penet^1,2, Jiangyang Zhang ¹, Kristine Glunde^1,2, and Zaver M. Bhujwalla^1,2

¹JHU ICMIC program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

The dense desmoplastic stroma present in pancreatic ductal adenocarcinoma (PDAC) limits the delivery of diagnostic imaging probes and therapeutic agents leading to poor prognosis of PDAC from a combination of late-stage diagnosis and limited response to chemotherapy. Collagen 1 (Col1) fibers form a major component of this desmoplastic stroma. By combining noninvasive diffusion MRI with optical imaging we characterized the relationship between Col1 fibers and diffusion MRI in PDAC. A good correlation was observed between Col1 fibers and diffusion MRI parameters providing a rationale for detecting PDAC with diffusion MRI, and characterizing the relationship between Col1 fibers and diffusion MRI.

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