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Abstract #2770

Measurement of Arteriolar Blood Volume in Brain Tumors Using MRI without Exogenous Contrast Agent Administration at 7T

Yuankui Wu1,2,3, Shruti Agarwal4, Craig K Jones2,3, Andrew G Webb5, Peter C.M. van Zijl2,3, Jun Hua2,3, and Jay J Pillai4

1Department of Medical Imaging, Nanfang Hospital, Southern Medical University, Guangzhou, China, People's Republic of, 2Neurosection, Div. of MRI Research, Dept. of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 4Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5Department of Radiology, C.J.Gorter Center for High Field MRI, University Medical Center, Leiden, Netherlands

The purpose of this study is to evaluate the potential diagnostic value of inflow-based vascular-space-occupancy (iVASO) MRI in brain tumor patients by comparing it with the widely used dynamic-susceptibility-contrast (DSC) MRI. The iVASO approach can measure arteriolar cerebral blood volume (CBVa) without using an exogenous contrast agent. The measured CBVa by iVASO showed a stronger association with tumor grade than DSC CBV. As the total scan times for iVASO and DSC are comparable, iVASO MRI may be a useful alternative for the assessment of tumor perfusion, especially when exogenous contrast agent administration is difficult or contraindicated in certain patient populations.

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