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Abstract #2771

An Extended Linear Reference Region Model that accounts for plasma volume in Dynamic Contrast Enhanced MRI

Zaki Ahmed1 and Ives Levesque1,2

1Medical Physics Unit, McGill University, Montreal, QC, Canada, 2Research Institute of the McGill University Health Centre, Montreal, QC, Canada

The reference region model allows quantification of tumour perfusion through DCE-MRI without needing an arterial input function. One limitation is that the model does not account for plasma volume which could be non-negligible in highly vascularized tissues such as tumours. This study introduces a reference region model that accounts for the plasma volume. The performance of this model is evaluated in simulation and invivo data.

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