Meeting Banner
Abstract #2772

Test-retest stability of MTT insensitive CBV leakage correction in DSC-MRI

Atle Bjørnerud1,2, Magne Mørk Kleppestø1, Tracy T Batchelor3,4, Patrick Y Wen5, Gregory Sorensen6, and Kyrre Eeg Emblem1,7

1The Intervention Centre, Oslo University Hospital, Oslo, Norway, 2Dept. of Physics, University of Oslo, Oslo, Norway, 3Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, 4Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, 5Center for Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, United States, 6Siemens Healthcare Health Services, Malvern, MA, United States, 7MGH-HST A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States

Contrast agent extravasation is known to be a serious confounder in estimations of cerebral blood volume (CBV) analysis of primary brain tumors using DSC-MRI. We here propose a modified MTT-insensitive method for correction of contrast agent extravasation based on parametric analysis of the tissue impulse response function from a two-compartment kinetic model combined with automated global arterial input function (AIF) approximation. Using DSC-MRI data from 28 patients with recurrent glioblastoma which were scanned twice prior to treatment initiation, we show that the proposed method yields test-retest stability similar to the current reference method, but with the added advantage of reduced MTT sensitivity.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords