Abstract #2773

Differential Diagnosis of Giant Cell Tumor and Chordoma in the Spine by Using Morphological Features and Pharmacokinetic Parameters Analyzed from DCE-MRI

Ning Lang¹, Hon J. Yu², Huishu Yuan¹, and Min-Ying Su²

¹Department of Radiology, Peking University Third Hospital, Beijing, China, People's Republic of, ²Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, CA, United States

26 patients with giant cell tumor in the spine and 12 patients with chordoma received DCE-MRI were analyzed. The morphological features (lesion location, vertebral compression, paraspinal soft tissue mass, bone expansion change, fiber separation, and MR signal on T1W1 and T2W1) and DCE pharmacokinetic parameters were compared. Several typical morphological features could be used for differential diagnosis, but there was a substantial overlap. DCE-MRI may provide very helpful information. Giant cell tumor had a significantly higher Ktrans and kep compared to chordoma, and by using a cut-off value of kep=0.43/min, it could achieve a very high accuracy of 95%.

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