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Abstract #2774

Characterization of Metastatic Cancer in the Spine by DCE-MRI: Comparison of Heuristic and Pharmacokinetic Parameters Analyzed from DCE Kinetics

Ning Lang1, Hon J. Yu2, Huishu Yuan1, and Min-Ying Su2

1Department of Radiology, Peking University Third Hospital, Beijing, China, People's Republic of, 2Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, CA, United States

A retrospective DCE-MRI of 76 patients with different metastatic cancers in the spine (35 lung, 11 thyroid, 12 breast, 7 prostate, 7 liver and 4 kidney) were studied. Three heuristic parameters: the maximum and steepest wash-in signal enhancement ratio and the wash-out slope were measured. Two-compartmental pharmacokinetic analysis was performed to obtain Ktrans and kep. The maximum and wash-in SE ratio were highly correlated with Ktrans; and the wash-out slope was highly correlated with kep. The lung cancer had the widest variation, the breast cancer had the highest wash-in SE ratio, and the thyroid cancer had the greatest wash-out slope.

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