Abstract #2775

DCE-MRI Evidence of Biological Changes in Irradiated Healthy Muscle Following Chemoradiotherapy Treatment of Head and Neck Cancer

Kimberly Li^1,2, Abdallah S.R. Mohamed³, Yao Ding⁴, Musaddiq J Awan⁵, Steven J Frank³, Jihong Wang⁶, John D Hazle⁴, Kate Hutcheson⁷, Stephan Y Lai⁷, Jayashree Kalpathy-Cramer⁸, Xin Li², Clifton D Fuller³, and Wei Huang²

¹International School of Beaverton, Beaverton, OR, United States, ²Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ³Department of Radiation Oncology, U.T. MD Anderson Cancer Center, Houston, TX, United States, ⁴Department of Imaging Physics, U.T. MD Anderson Cancer Center, Houston, TX, United States, ⁵Department of Radiation Oncology, Case Western Reserve University, Cleveland, OH, United States, ⁶Department of Radiation Physics, U.T. MD Anderson Cancer Center, Houston, TX, United States, ⁷Department of Head and Neck Surgery, U.T. MD Anderson Cancer Center, Houston, TX, United States, ⁸Harvard Medical School, Boston, MA, United States

Head and neck cancer patients are commonly treated with chemoradiotherapy as standard of care. Although the conventional wisdom is that radiation does not cause long-term adverse effects in healthy, well-perfused tissues such as muscle, few studies have evaluated potential biological changes in irradiated muscle tissues longitudinally during the course of treatment. Here, we report preliminary findings of such changes as measured by Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) before, during, and after chemoradiotherapy treatment of a subset of human papilloma positive (HPV+) oropharyngeal cancer (OPC).

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