Abstract #2776

Reliability of DCE pharmacokinetic parameter values for quantitative longitudinal assessment of brain tumors

Moran Artzi¹, Gilad Liberman^2,3, Deborah Blumenthal⁴, Orna Aizenstein¹, and Dafna Ben Bashat^1,5

¹Functional Brain Center, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel, ²Functional Brain Centerasky Medical Cente, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel, ³Department of Chemical Physics, Weizmann Institute, Rehovot, Israel, ⁴Neuro-Oncology Service, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel, ⁵Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel-Aviv, Israel

DCE-MRI parameters have been shown to be useful for therapy response assessment in patient with glioblastoma, yet the estimated parameters may show high variation in their values. This study investigated the reliability of DCE parameters for quantitative longitudinal assessment of brain tumors. 14% standard-deviation in the WM and 12% in the GM, were detected for v_p in healthy subjects(n=27). Results from six patients showed mean differences of 3.2%/9.7% in v_pfor WM/GM in the hemisphere contralateral to the lesion, comparing two longitudinal scans. Parametric-response-maps calculated within lesion areas based on the threshold values from the healthy controls supported radiological assessment.

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