Abstract #2781

Comparison of DCE-MRI using Gd-EOB-DTPA and Gd-DTPA for tumor vascularity evaluation for hepatoma: preclinical study using rat orthotopic hepatoma model.

Jimi Huh¹, Kyung Won Kim¹, Chang Kyung Lee¹, Jisuk Park¹, In Seong Kim², Su Jung Ham¹, and Bumwoo park¹

¹radiology, Asan medical cencer, Seoul, Korea, Republic of, ²Siemens Healthcare, Seoul, Korea, Republic of

For evaluation of tumor vascularity of hepatoma, we aim to compare the DCE-MRI using Gd-EOB-DTPA and Gd-DTPA. When we perform DCE-MRI twice with 24-hours interval: first scan using Gd-DTPA and second scan using Gd-EOB-DTPA, the time-intensity curve patterns were quite different between the two scans. These findings imply that Gd-DTPA distributes between blood vessels and EES, working as a extracellular contrast agent, whereas Gd-EOB-DTPA distribute blood vessels, EES, and intracellular space in the hepatoma, working as a hepatobiliary contrast agent. Therefore, the conventional two-compartment model does not fit DCE-MRI using Gd-EOB-DTPA in subjects with hepatoma which may express OATP receptors.

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