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Abstract #2781

Comparison of DCE-MRI using Gd-EOB-DTPA and Gd-DTPA for tumor vascularity evaluation for hepatoma: preclinical study using rat orthotopic hepatoma model.

Jimi Huh1, Kyung Won Kim1, Chang Kyung Lee1, Jisuk Park1, In Seong Kim2, Su Jung Ham1, and Bumwoo park1

1radiology, Asan medical cencer, Seoul, Korea, Republic of, 2Siemens Healthcare, Seoul, Korea, Republic of

For evaluation of tumor vascularity of hepatoma, we aim to compare the DCE-MRI using Gd-EOB-DTPA and Gd-DTPA. When we perform DCE-MRI twice with 24-hours interval: first scan using Gd-DTPA and second scan using Gd-EOB-DTPA, the time-intensity curve patterns were quite different between the two scans. These findings imply that Gd-DTPA distributes between blood vessels and EES, working as a extracellular contrast agent, whereas Gd-EOB-DTPA distribute blood vessels, EES, and intracellular space in the hepatoma, working as a hepatobiliary contrast agent. Therefore, the conventional two-compartment model does not fit DCE-MRI using Gd-EOB-DTPA in subjects with hepatoma which may express OATP receptors.

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