Abstract #2782

Similarity of In Vivo Lactate T1 and T2 Relaxation Times in Different Preclinical Cancer Models Facilitates Absolute Quantification of Lactate

Ellen Ackerstaff¹, Nirilanto Ramamonjisoa¹, H. Carl LeKaye¹, Kristen L. Zakian¹, Ekaterina Moroz¹, Inna S. Serganova¹, Ronald G. Blasberg¹, and Jason A. Koutcher¹

¹Memorial Sloan Kettering Cancer Center, New York, NY, United States

Aggressive, treatment-resistant tumors have been associated with high tumor lactate. For the absolute quantification of in vivo tumor lactate by the substitution method, it is essential to correct for differences between reference phantom and in vivo lactate T₁ and T₂ relaxation times (LacT₁/T₂). The LacT₁/T₂ acquisition requires specialized MR sequences and is hampered in vivo by long acquisition times and low lactate SNR. Here, we measure LacT₁/T₂ for various orthotopic breast and subcutaneous prostate cancer models in immune-competent and immune-compromised hosts. Our results indicate that using an average LacT₁/T₂ correction factor introduces less than 20% error in the lactate quantification.

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