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Abstract #2782

Similarity of In Vivo Lactate T1 and T2 Relaxation Times in Different Preclinical Cancer Models Facilitates Absolute Quantification of Lactate

Ellen Ackerstaff1, Nirilanto Ramamonjisoa1, H. Carl LeKaye1, Kristen L. Zakian1, Ekaterina Moroz1, Inna S. Serganova1, Ronald G. Blasberg1, and Jason A. Koutcher1

1Memorial Sloan Kettering Cancer Center, New York, NY, United States

Aggressive, treatment-resistant tumors have been associated with high tumor lactate. For the absolute quantification of in vivo tumor lactate by the substitution method, it is essential to correct for differences between reference phantom and in vivo lactate T1 and T2 relaxation times (LacT1/T2). The LacT1/T2 acquisition requires specialized MR sequences and is hampered in vivo by long acquisition times and low lactate SNR. Here, we measure LacT1/T2 for various orthotopic breast and subcutaneous prostate cancer models in immune-competent and immune-compromised hosts. Our results indicate that using an average LacT1/T2 correction factor introduces less than 20% error in the lactate quantification.

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