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Abstract #2783

Multiparametric MRI of a transgenic mouse model of neuroblastoma using an asymmetric high resolution 3-channel/3-animal RF coil on a clinical 3T platform

Gilberto S Almeida1, Rafal Panek1,2, Albert Hallsworth3, Hannah Webber3, Efthymia Papaevangelou1, Jessica KR Boult1, Yann Jamin1, Louis Chesler3, and Simon P Robinson1

1Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom, 2The Institute of Cancer Research/ Royal Marsden NHS Foundation Trust, London, United Kingdom, 3Cancer Therapeutics and Clinical Studies, The Institute of Cancer Research, London, United Kingdom

The use of clinical MRI scanners to conduct preclinical research facilitates a more direct or matched comparison with clinical studies. The increased use of orthotopic and transgenic mouse tumour models in cancer research demands non-invasive methods to accurately assess their progression and treatment response in vivo. The purpose of this study was to evaluate the utility and sensitivity of anatomical and functional MRI data/biomarkers acquired from transgenic mouse models of neuroblastoma using a non-bespoke asymmetric high resolution RF coil on a clinical 3T scanner.

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