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Abstract #2784

Early MRI findings after Near Infrared Photoimmunotherapy in an animal model

Yuko Nakamura1, Marcelino Bernardo1, Tadanobu Nagaya1, Kazuhide Sato1, Toshiko Harada1, Peter L. Choyke1, and Hisataka Kobayashi1

1Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States

Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with the toxicity induced by photon absorbers after irradiation with NIR light. The purpose of this study was to determine if MR imaging can detect changes in the MR properties of tumor within several hours of NIR-PIT in an animal model. Prolongation of T2, reductions in apparent diffusion coefficient (ADC) and increased enhancement using gadofosveset are seen within 2 hours of NIR-PIT treatment of tumors. Thus, MRI can be a useful imaging biomarker for detecting early therapeutic changes after NIR-PIT.

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